الأشعار

  • حوار الصحافة – رمضان يوليو 2012 كيف تستقبل شهر رمضان وماذا يمثل لك أستقبله كشهر له نكهة خاصة واحساس مختلف فهو يمثل غذاء للروح أكثر م
  • لقاء صحيفة المريخ أبدأ بسيرة ذاتية مختصرة ثم أواصل.. معز عمر بخيت – من مواليد مدينة أمدرمان – بيت المال. سكنت الخرطوم
  • لقاء شبكة ومنتديات الحفير شبكة ومنتديات الحفير: نرحب بسعادة الدكتور معز عمر بخيت، ونشكرك على قبول هذه الدعوة الكريمة…..
  • لقاء دكتور المعز – قوون 1)متي أحسست بموهبة الشعر ؟ منذ المرحلة المتوسطة 2)متي كتبت اول قصيدة ؟ في المرحلة الثانوية العليا 3)


كتبي

Scientific Portfolio

(Total impact factors 350)
1990
  • Bakhiet M, Olsson T, Van der Meide P and Kristensson K. Depletion of CD8+ T cells suppresses growth of T. brucei brucei and IFN- production in infected rats. Clin Exp Immunol; 81: 195-199. 1990.
1991
  • Olsson T, Bakhiet M, Edlund C, Höjeberg B, Van der Meide P, and Kristensson K. Bidirectional activating signals between Trypanosoma brucei and CD8+ T cells: a trypanosome-released factor triggers interferon gamma production that stimulate parasite growth. Eur J Immunol; 21: 2447-2454. 1991.
  • Nitin G, Bakhiet M, Kristensson K, Norrby E and Olsson T. Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain. J Neuroimmunol 31: 19-26. 1991.
1992
  • Eneroth P, Bakhiet M Olsson T, Kristensson, K. Bidirectional signals between Trypanosoma brucei brucei and dorsal root ganglia neurons. J Neurocytol 21:846-852. 1992.
  • Olsson T, Bakhiet M and Kristensson K. Interactions between Trypanosoma brucei and CD8+ T cells. Parasitology Today 8: 237- 239. 1992.
1993
  • Olsson T, Bakhiet M, Höjeberg B, Ljungdahl Å, Edlund C, Andersson G, Ekre H-P, Fung Leung W-P, Mak T, Wigzell H, Fiszer U, Kristensson K. CD8 is critically involved in lymphocyte activation by a Trypanosoma brucei brucei released molecule. Cell. 72: 715-727. 1993.
  • Bakhiet M, Mix E, Kristensson K, Wigzell H and Olsson T. T cell activation by a Trypanosoma brucei brucei derived lymphocyte triggering factor is dependent on tyrosine protein kinases but not on protein kinase C and A. Eur J Immunol. 23: 1535-1539. 1993.
  • Rottenberg M, Bakhiet M, Olsson T, Mak T, Wigzell H and Örn A. Differential susceptibility of CD4 and CD8 “knock out” mice to infections with Trypanosoma brucei or Trypanosoma cruzi. Infect. Immun. 61: 5129-5133. 1993.
  • Bakhiet M, Olsson T, Edlund C, Höjeberg B, Holmberg K, Lorentzen J and Kristensson K. A Trypanosoma brucei brucei derived factor that triggers CD8+ lymphocytes to interferon gamma secretion: Purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor. Scand. J. Immunol. 37: 165-178. 1993.
1994
  • Olsson T, Kelic S, Edlund C, Bakhiet M, Höjeberg B, van de Meide P, Ljungdahl Å and Kristensson K. Neuronal interferon gamma-like immunoreactive molecule, bioactivities and Purification. Eur. J. Immunol. 24: 308-314. 1994.
1995
  • Zhang G-X, Ma C-G, Bakhiet M, Olsson T and Link H. Depletion of CD8+ T cells has protective effect on experimental autoimmune Myasthenia Gravis in Lewis rats. Eur. J. Immunol. 25: 1191-1198. 1995.
  • Bonfanti C, Caruso A, Bakhiet M, Olsson T, Turano A and Kristensson K. Increased levels of antibodies to IFN- in human and experimental African trypanosomiasis. Scand. .J Immunol. 41: 49-52. 1995.
  • Zhang G-X, Ma C-G, Bakhiet M, Olsson T and Link H. Suppression of experimental autoimmune Myasthenia Gravis after CD8 depletion is associated with decreased IFN-g and IL-4. Scand. J. Immunol. 42: 457-465. 1995.
1996
  • Zhang G-X, Xia B-G, Bakhiet M., Wigzell H. and Link H. Both CD4+ and CD8+ are essential to induce experimental autoimmune Myasthenia Gravis. J. Exp. Med. 184: 349-356. 1996.
  • Bakhiet M., Jansson L., Büscher P., Holmdahl R., Kristensson K. and Olsson T. Control of parasitemia and survival during Trypanosoma brucei brucei infection is related to strain dependent ability to produce interleukin-4. J. Immunol. 157: 3518-3526. 1996.
  • Bakhiet M, Olsson T., Mhlanga J., Büscher P, Lycke N., Van der Meide P and Kristensson K. Human and rodent IFN-g as a growth factor for Trypanosoma brucei brucei. Eur. J. Immunol. 26: 1359-1364. 1996.Bakhiet M, Olsson T, Ljungdahl Å, Höjeberg B, Van der Meide P, Kristensson K. Induction of Interferon-, Transforming growth factor-b and interleukin-4 in mouse strains with different susceptibility to Trypanosoma brucei brucei. J. Interf. Cytok. Res. 16: 427-433. 1996.
  • Andersson M, Löv P. and Bakhiet M. Lovastatin inhibits interferon-g-induced Trypanosoma brucei brucei proliferation: evidence for mevalonate pathway involvement. J. Interf. Cytok. Res. 16: 435-439. 1996.
  • Bakhiet M, Büscher P, Kristensson K, Wigzell H and Olsson T. Different Trypanozoon species possess CD8 dependent lymphocyte triggering factor-like activity. Immunol. Letters. 50: 71-80. 1996.
1997
  • Vaidya T. Bakhiet M, Olsson T., Kristensson K. and Donelson J. The gene for a T-lymphocyte triggering factor from African trypanosomes. J Exp Med 186: 433-438. 1997.
  • Akuffo H, Maasho K, Blomstedt M, Höjeberg B, Britton S and Bakhiet M. Promastigotes of Leishmania aethiopica derived from diffuse cutaneous leishmaniasis patients preferentially induce mRNA for IL-10 while those from local cutaneous leishmaniasis patients induce interferon gamma. J. Infect. Dis. 175: 737-741. 1997.
  • Mustafa E., Bakhiet M., Jaster R., Bittorf T., Mix E. and Olsson T. Tyrosine kinases are required for interferon- stimulated proliferation of Trypanosoma brucei brucei. J. Infect. Dis. 175: 669-673. 1997.
  • Bakhiet M, Diab A, Mustafa M, Zhu J, Lindqvist L and Link H. Potential role of autoantibodies in the regulation of cytokine responses in bacterial infections. Infect. Immun. 65: 3300-3303. 1997.
  • Raqib R, Gustafsson A, Ljungdahl Å and Bakhiet M. A systemic downregulation of gamma interferon production is associated with acute shigellosis.Infect Immun. 65: 5338-5341. 1997.
  • Diab A, Zhu J, Lindqvist L, Wretlind B, Bakhiet M. and Link H. Haemophilus influenzae and Streptococcus pneumoniae induce different pattern of intracerebral cytokines during the course of experimental bacterial meningitis. Clin. Exp. Immunol. 109: 233-241. 1997.
  • Khalil A., Bakhiet M., Brauner A and Taullus K. Cytokine gene expression in kidneys of mice experimentally infected with Escherichia coli. J. Urol. 158: 1567-1580. 1997.
  • Diab A, Zhu J, Lindqvist L, Wretlind B, Link H and Bakhiet M. Cytokine mRNA profiles during the course of experimental Haemophilus influenzae bacterial meningitis. Clin Immunol. Immunopathol. 85: 236-245. 1997.
  • Mustafa A., Nyberg F., Mustafa M., Bakhiet M., Mustafa E. and Adam A. Growth hormone stimulates production of IFN-g in human mononuclear cells. Horm. Res. 48: 11-15. 1997.
1998
  • Abdel-Halim S, Guenifi A, Bing H, Mustafa M, Höjeberg B, Hillert J, Bakhiet M, and Evendic S. Mutations of adenylate cyclase gene, enhanced expression of adenylate cyclase mRNA and generation of cAMP in the spontaneously diabetic GK rat islets. Diabetes. 47: 498-504. 1998.
  • Elkarim R., Mustafa M., Link H. and Bakhiet M. Cytokine Autoantibodies in multiple sclerosis, Aseptic meningitis and stroke. Eur. J. Clinic. Invest. 28: 295-299. 1998.
  • Mousa A, Mustafa M Wallberg L, Seiger Å and Bakhiet M. Interactions between human embryonic forebrain cells, interferon-g and interleukin-4. Int J Mol Med. 1: 172-176. 1998.
  • Eltayeb R, Mustafa M, Kristensson K, Olsson T, Lycke N, van der Meide P-H. and Bakhiet M. Cytokines and anti-cytokine autoantibodies during experimental African trypanosomiasis in mice with disrupted IFN-g and IFN-g receptor genes. Int J Mol Med. 1: 177-183. 1998.
  • Bakhiet M, Mustafa M, Zhu J, Lindqvist L, Link H and Diab A. Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid during experimental bacterial meningitis in rats. Clin. Exp. Immunol. 114: 398-402. 1998.
  • Elkarim R., Mustafa M., Link H. and Bakhiet M. Recovery from Guillain-Barrié syndrome is associated with increased levels of neutralizing autoantibodies to IFN-g. Clin. Immunol. Immunopathol. 88: 241-248. 1998.
  • Li H, Shi FD, He B, Bakhiet M, Wahren B, Berglöf A, Sandsted K and Link H. Experimental autoimmune myasthenia gravis induction in B cell deficient mice. Int Immunol. 10: 1359-1365. 1998.
  • Zhu J, Deng GM, Diab A, Zwingenber K, Zhou JN, Bakhiet M, Link H. Thalidomide exacerbates experimental autoimmune neuritis in Lewis rats. Scan J Immunol. 48: 397-402. 1998
  • Zhu J, Zou LP, Bakhiet M, Mix E. Resistance and susceptibility to experimental autoimmune neuritis in Sprague-Dawley and Lewis rats correlate with different levels of autoreactive T and B cells responses to myelin antigens. J Neurosci Rec. 54: 373-381. 1998.
  • Mousa A, Mustafa A, Seiger Å, Kjaeldgaard A and Bakhiet M. Tyrosine kinases are potentially involved in growth stimulation of human first trimester forebrain cells by interferon-. Neuroreport. 9: 4097-4101. 1998.
  • Mousa A, Seiger Å, Kjaeldgaard A and Bakhiet M. Human first trimester forebrain cells express genes for inflammatory and anti-inflammatory cytokines. Cytokine. 11: 55-60. 1998.
1999
  • Bakhiet M, Özenci V., Withagen C, Fredrikson S and Link H. A new cell enzyme-linked immunosorbent assay demonstrates gamma interferon suppression by beta interferon in multiple sclerosis. Clin Diagn Lab Immunol. 6: 415-9. 1999.
  • Bakhiet M, Elkarim R, Diab A, Zhu J, Lindqvist, L Link H and Mustafa M. A novel mechanism for cytokine regulation: Screening, selection and characterisation of anti-cytokine monoclonal and polyclonal autoantibodies. J Interf. Cytok. Res. 19: 439-445. 1999.
  • Diab A, Li H-L, Zhu J, Lindquist L, Wretlind B., Bakhiet M and Link, H. Neutralization of MIP-2 and MIP-1a attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis. Infect. Immun. 67: 2590-601. 1999.
  • Hamadien M, Lycke N and Bakhiet M. Induction of the trypanosome lymphocyte triggering factor and its antibodies in mice with different susceptibilities to African trypanosomiasis. Immunology. 96: 606-611. 1999.
  • Elkarim R., Mustafa M., Lindqvist L., Link H. and Bakhiet M. Levels of gamma interferon and interleukin-4 are inversely related to the levels of their corresponding autoantibodies in patients with lower respiratory tract infection. Infect Immun. 67:3051-4. 1999.
  • Elkarim R., Mustafa M., Ekerfelt C., Ernerudh J., Link H. and Bakhiet M. Induction of neutralizing autoantibodies to interferon-gamma in patients with polyneuropathy. Hum. Antibodies. 9: 55-60. 1999.
  • Zhu J, Bai XF, Björk J, Hedlund G, Bakhiet M, Link H. Linomide suppresses experimental allergic neuritis in Lewis rats by inhibiting myelin antigen-reactive T and B cells responses. Clin. Exp. Immunol. 115: 56-63. 1999.
  • Liu Y, Li Z and Bakhiet M. Upregulation of the chemokines Rantes, MCP-1, MIP-1a and MIP-2 in early infection with Trypanosoma brucei brucei and inhibition by sympathetic denervation of the spleen. Trop. Med. Int. Health. 4: 85-92. 1999
  • Sharafeldin A, Hamadien M, Diab A, Khalil A, Li H-L, Shi F-D, and Bakhiet M. Cytokine profiles in the central nervous system and the spleen during the early course of experimental African Trypanosomiasis in rat. Scand. J. Immunol. 50:256-261. 1999.
  • Xiao B-G., Mousa A., Kivisäkk P, Bakhiet M. and Link H. Induction of b-family chemokines mRNA in human embryonic astrocytes by inflammatory cytokines and measles virus. J. Neurocytol. 27: 575-80. 1999.
  • Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J. Interferon. Cytokine Res. 19: 1047-1052. 1999.
  • Liu Y, Li Z, Nuortio L and Bakhiet M. Interferon-g and interleukin-12 genes are preferentially expressed during early experimental African trypanosomiasis and suppressed by splenic denervation of the spleen. Scand. J. Immunol. Scand. J. Immunol. 50: 485-91. 1999.
  • Wang HB, Li H, He B, Bakhiet M, Levi M, Wahren B, Berglof A, Sandstedt K, Link H, Shi FD. The role of B-cells in experimental myasthenia gravis in mice. Biomed Pharmacother 53:227-33. 1999.
  • Bakhiet M. The role of autoantibodies in the action of cytokines. Frontiers in multiple sclerosis III. EDS: Martin Dunitz Ltd, London. 1999.
2000
  • Eltayeb R, Sharafeldin A, Robert Jaster, Thomas Bittorf, Mix E and Bakhiet M. Trypanosoma brucei brucei induces interferon-g expression in rat dorsal root ganglia cells via a Tyrosine protein kinase-dependent pathway. J. Infect. Dis. 181: 400-404. 2000
  • Sharafeldin A, Eltayeb R, Patchenkov Ml and Bakhiet M. Chemokines are produced in the brain early during the course of experimental African trypanosomiasis. J Neuroimmunol. 103: 165-170. 2000.
  • Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Orthodontic movement induces high numbers of cells expressing IFN-g at mRNA and protein levels. J. Interf. Cytok. Res. 20: 7-12. 2000.
  • Hamadien M, Bakhiet M and Harris R. Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. Parasitology. 120: 281-287. 2000.
  • Nordlind K, Eriksson L, Seiger Å and Bakhiet M. Expression of interleukin-6 in human spinal ganglion cells. Neuroscience Letters. 280: 139-142. 2000.
  • Khalil A, Tullus K, Bakhiet M, Burman LG, Jaremko G and Brauner A. Angiotensin II type 1 receptor antagonist (Losartan) reduces transforming growth factor-b in experimental acute pyelonephritis. J. Urol. 164:186-191. 2000.
  • Mustafa M, Bakhiet M, Wondimu Band Modéer T. Induction of interferon-g in human gingival fibroblasts challenged with phytohemagglutnin. Cytokine. 12: 368-73. 2000.
  • Khalil A., Bakhiet M., Taullus K. and Brauner A. Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6 deficient mice. Clin. Exp. Immunol. 122: 200-206. 2000.
  • Falsafi-Amin H, Lundberg L, Bakhiet M and Nordlind K. Early DNA synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects. Int. Arch. Allergy Immunol. 123:170-176. 2000.
  • Mustafa M, Modéer T and Bakhiet M. Effect of triclosan on interferon-gamma production and major histocompatibility complex class II expression in human gingival fibroblasts. J. Clin. Periodontol. 27: 733-737. 2000.
  • Liu Y, Mustafa M, Li H-L, Nuortio L, Mustafa A and Bakhiet M. Modulation of early immune responses and suppression of Trypanosoma brucei brucei infections by surgical denervation of the spleen. Neuroimmunemodulation. 8: 31-38. 2000.
  • Grant K, Abdalla H, Diab A, Lindquist L, Bakhiet M and Andersson J. Suppression of macrophage activation with CNI-1493 increases survival in infant rats with systemic Haemophilus influenzae infection. Infect Immun. 68: 5329-34. 2000.
2001
  • Bakhiet M, Tjernlund A, Mousa A, Gad A, Strömblad S, Seiger Å and Andersson J. Rantes promotes growth and survival of human first trimester forebrain astrocytes. Nature CB. 2: 150-157. 2001.
  • Alhashimi N, Frithiof L, Brudvik P and Bakhiet M. Orthodontic movement induces de novo synthesis of proinflammatory cytokines. Am. J. Orthod. Dentofacial Orthop. 119: 307-312. 2001
  • Mustafa M, Wondimu B, Bakhiet M, Modéer T. Production of Rantes/CCL5 in human gingival fibroblasts challenged with tumor necrosis factor alpha. Eur. J. Oral Sci. 109: 44-9. 2001.
  • Nylen S, Mortberg U, Kovalenko D, Satti I, Engstrom K, Bakhiet M, Akuffo H. Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors. Clin. Exp. Immunol.124: 43-53. 2001.
  • Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry-Central Nervous System. 1: 201-208.2001.
  • Bakhiet M, Mousa A, Seiger A, Andersson J. Constitutive and inflammatory induction of alpha and beta chemokines in human first trimester forebrain astrocytes and neurons. Mol Immunol 38: 921-929. 2001.
2002
  • Bakhiet M, Hamadien M, Tjernlund A, Mousa A and Seiger Å. African trypanosomes activate human embryonic forebrain cells to proliferation and IFN-g production. NeuroReport. 13: 53-56. 2002.
2003
  • Hertting O, Khalil A, Jaremko G, Chromek M, Li YH, Bakhiet M, Bartfai T, Tullus K, Brauner A Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice. Clin Exp Immunol 131:2 225-33. 2003.
  • Chen Z, Yu S, Bakhiet M, Winblad B, Zhu J. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. J Neurochem. 86: 61-68. 2003.
  • Al-Sallom FS, Al-Mahmeed A, Ismaeel A, Botta GA, Bakhiet M. Campylobacter-stimulated INT407 cells produce dissociated cytokine profiles. J Infect. 47: 217-24. 2003.
2004
  • Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. CD40-CD40L expression during orthodontic tooth movement in rats. Angle Orthod. 74:100-105. 2004.
  • Bakhiet M, Al-Salloom FS, Qareiballa A, Bindayna K, Farid I, Botta GA,. Induction of alpha and beta chemokines by intestinal epithelial cells stimulated with Campylobacter jejuni. J Infect. 48: 236-44. 2004.
  • Liu Y, Li Z, Svaren-Quiding C, Cui J, Ozenci V, Bakhiet M. Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats. Neuroimmunomodulation. 11: 113-8. 2004.
  • Ahmed Sharafeldin, Eilhard Mix, Robert Harris Tomas Bittroff and Moiz Bakhiet. Prolonged Activation of Transcription Regulating Factors in Trypanosoma brucei brucei Nuclear Proteins by Interferon-g Stimulation. Acta Protozool. 43: 373 – 377. 2004.
2005
  • Ismaeel A, Al-Mahmeed A , Qareiballa A, Bakhiet M and Botta GA. Effect of anti sub inhibitory concentration on cytolethal distending toxin production by Campylobacter jejuni. J Infect. 51: 144-149. 2005.
2006
  • Sameer Otoom, Moiz Bakhiet, Abdulmajeed Khan, Reginald Sequeira. Prolonged use of Phenytoin, Carbamazepine or Valproate Monotherapy on Plasma Prolonged use of phenytoin, carbamazepine or valproate monotherapy on plasma levels of folate and B(12): a comparison between epileptic patients with or without cardiovascular disorders. Neuro Endocrinol Letters, 27: 85-88. 2006.
  • Moiz Bakhiet, Li-Ya Yu, Volkan Özenci, Abdulmajeed Khan and Fu-Dong Shi. Modulation of immune responses and suppression of experimental autoimmune myasthenia gravis by surgical denervation of the spleen. Clin Exp Immunol. 2006: 144: 290–298.
  • Habib Al-yosif, Safa Taha, Moiz BakhietHabib. Cytokine gene polymorphism in Bahraini patients with coronary heart disease. Arab Gulf Journal of Scientific Research. 24: 144-150. 2006.
2007
  • Ali Al-Bahrani, Safa Taha, Husain Shaath and Moiz Bakhiet. TNF-α and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents. Curr. Neurvascular Res. 4: 31-37. 2007.
  • Alyaa Mousa, Amani Al-Zaki, Safa Taha and Moiz Bakhiet. Induction of the chemokines CCL3a, CCL3b and CCL5 in atherosclerotic patients. Am J Immunol. 3: 45-51, 2007.
2008
  • Moiz Bakhiet and Safa Taha. A novel nervous system-induced factor inducing immune responses in the spleen. Imm Cell Biol. 86:688-699. 2008.
  • Ahlam Al-Amri, Giuseppe Botta, Khaled Tabbara, Abdelrahman Ismaeel, Ali Al-Mahmeed, Ahmed Qareeballa, Khalid Bin Dayna, and Moiz Bakhiet. Campylobacter jejuni induces diverse kinetics and profiles of cytokine genes in INT-407 cells. Saudi Med J. -51. 2008
  • Alyaa Mousa, Amani Al-Zaki, Safa Taha and Moiz Bakhiet. Induction of the anti-inflammatory cytokines interleukin (IL)-10, IL-13 in atherosclerotic patients. Arab Gulf Journal of Scientific Research, 26: 86-94. 2008.
2009
  • Alyaa Mousa, Amani Al-Zaki, Safa Taha and Moiz Bakhiet Induction of interleukin (IL)-IL-18 in atherosclerotic patients: A role for Chlamydia pneumoniae. Med Princ Pract. 2009; 18: 105-10. 2009.
  • Almawi WY, Khan A, Al-Othman SS, Bakhiet M. 1.Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke. J Stroke Cerebrovasc Dis. 18: 407-408. 2009.
2010
  • Ali Al-Bahrani, Habib Alyousef, Basem Mustafa, Meytham Majeed, Moiz Bakhiet. A possible role for Chlamydia pneumoniae in vaso-occlusive crisis in sickle cell disease. Bahrain Medical Bulletin, 32: 111-117. 2010.
  • Ali Al-Bahrani, Safa Taha, Husain Shaath and Moiz Bakhiet Acute ischemic brain stroke is associated with the consequences of Chlamydia pneumoniae infection. J Bah Med Soc. 22: 146 – 150. 2010.
2011
  • Abdelhad Al-Bannawi, Khulood Al-Wesebai, Safa. Taha and Moiz Bakhiet Chlamydia pneumoniae induces chemokine expression by platelets in patients with atherosclerosis. Med Princ Pract. 20: 438-443. 2011
Submitted
  • Twenty one (21) papers are submitted recently
  • Summary of overview articles and chapters in text-books
  • Olsson T, Bakhiet M and Kristensson K. Interactions between Trypanosoma brucei and CD8+ T cells. Parasitology Today 8: 237- 239. 1992.
  • Bakhiet M. The role of autoantibodies in the action of cytokines. Frontiers in multiple sclerosis III. EDS: Martin Dunitz Ltd, London. 1999.
  • Moiz Bakhiet. Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for interferon-b in the treatment of multiple sclerosis. Current Medicinal Chemistry- Central Nervous System. 1: 201-208.2001.

Research resulted in International Patents:

Lymphocyte stimulating factor-P-CA2998004, AWAPATENT, International patent 2000

Immune System Mediator UK, Patent Number: 0703887.0 / PCT/EP2008/052399

  • Summary of other scientific work
Ph.D. Examination Committees
  • Ph.D. thesis of Dr. Bao-Gua Xiao, 8/11/1996.
  • Ph.D. thesis half-time exam of Dr. Bai Xuefeng 3/3/1997
  • Ph.D. thesis of Dr. Tiamin Liu, 28/11/1997.
  • Ph.D. thesis of Dr. Anna-Fogdell, 19/12/1997
  • Ph.D. thesis of Dr. He Bing, June 1998
  • Ph.D. thesis of Dr. Fo-Dong, May 1998
  • Ph.D. thesis of Dr. Chun Xu, May 1999
  • Ph.D. thesis of Mats Remberger, October 1999
  • Ph.D. thesis of Li-Ping Zou, December 1999
Potential reviewer for the following journals:
  • Infection and Immunity
  • Parasitology Today
  • Parasite Immunology
  • Scandinavian Journal of Immunology
  • Immunology Letters
  • Brain Research Bulletin
  • Neuroimmunemodulation
  • Nature Cell Biology
  • Journal of Odontology
  • The Angle Orthodontist
  • Bahrain Medical Bulletin
  • Arab Gulf Journal of Scientific Research
  • Saudi Medical Journal
  • Bahrain Medical Bulletin
  • Journal of Bahrain Medical Society
Member of the Editorial Board of ISRN Immunology

Member of the Editorial Board of DNA and Cell Biology

Member of the Editorial Board of Arab Gulf Journal of Scientific Research

Member of the Editorial Board of Bahrain Medical Bulletin

Member of the Editorial Board of Journal of Bahrain Medical Society (JBMS)

Potential reviewer for several foundations in relation to grant applications

 

Expert on the following techniques

Beside clinical experience in Medical Neurology procedures, I have the experience on the following techniques:
IMMUNOLOGY:
  1. Immunospot assay (ELISPOT)
  2. Proliferation assay
  3. Monoclonal making (immunization, hybridoma making, cell cloning and purification)
  4. Enzyme Linked Immunosorbant assay
  5. Western blot, SDS page blotting
  6. Immunohistochemistry
  7. Cells Enrichment assays
  8. Affinity purification techniques
  9. FACS techniques and analysis
MOLECULAR BIOLOGY:
  1. Restriction of DNA, isolation of total and mRNA
  2. Agarose gel electrophoresis
  3. PCR technique
  4. Ligation of PCR products, transformation and plating of transformed bacteria.
  5. Southern blotting
  6. Preparation of plasmid DNA and restriction analysis
  7. Amino acid gel sequencing
  8. DNA sequencing
  9. cDNA gene library construction and screening
  10. In situ hybridization
EXPERIMENTAL MODELS IN MICROBIOLOGY AND IMMUNIOLGY:
  1. Animal model for experimental trypanosomiasis
  2. Animal model for bacterial infections (meningitis, UTI)
  3. Experimental models for viral infections (VSV, Measles, Mumps)
  4. Animal model for Autoimmune diseases (myasthenia gravis, EAE, EAN
GENERAL:
  1. Microscope, image analysis and photo techniques
  2. Medical statistics
  3. Computer applications in IBM (DOS and Windows applications, in addition to experience in IBM hardware), and in Macintosh software.
  4. Bioinformatics

Summary of abstracts

  • Bidirectional activating signals between T. b. brucei and CD T cells. International meeting on lymphoid cells and molecules in infection and immunity, Elsinore, Denmark.14/5/1991.
  • CD8 is critically involved during Experimental African trypanosomiasis. First “Acrival Meeting” on chemotherapy of trypanosomiasis, Marseilles, France.15-16 /6/ 1992.
  • IFN-g as a growth promoting molecule for T. b. brucei. Commission of the European Community, COST Co-operation, Second Acrival COST meeting on Treatment African Trypanosomiasis, University of Budapest, Hungary. 3-4 /6/ 1993.
  • Interactions between T. b. brucei and CD8+ lymphocytes. 27th Trypanosomiasis Seminar. London School of Hygiene and Tropical Medicine, UK.15-16 /6/ 1993.
  • Bidirectional signals between T. b. brucei and dorsal root ganglia. 4th International Congress of neuroimmunology, RAI, Amsterdam, Holland. 22/10/1994.
  • African Trypanosomes and Immunoregulating Molecules. Medical Faculty of the University of Gothenburg. XXVIth Annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.25/5/1995.
  • Interactions between T. b. brucei and immunoregulating molecules. 9th International Congress of Immunology. San Francisco, USA.23-29 /7/ 1995.
  • Interactions between T. b. brucei and immunoregulating molecules. BSP seminar on trypanosomiasis and leishmaniasis, Glasgow, UK.2-6 /9/ 1995.
  • Immunobiolog of T. b. brucei. BSP symposium on immunobiology of trypanosomiasis and leishmaniasis, Glasgow, UK.3/9/1995.
  • Pathogenesis of Shigellosis. International cytokine symposium, UK, September 1995.
  • Interactions of Trypanosoma brucei brucei and the immune system. Trypanosome workshop, BMC, Uppsala .19/1/1996.
  • Role of IL-4 in control of parasitaemia and survival in resistant and susceptible mouse strains to Trypanosoma infection, Cytokine and cytokine receptor workshop, Turku, Finland. 25/5/1996
  • Interferon-b-1b treatment of multiple sclerosis patients suppresses both myelin basic protein-specific and pha-induced interferon-g production: an effect demonstrated by a new cell released capturing (crc)-elisa. Swedish Medical Association Annual meeting, Stockholm, Sweden. 29/11/1996.
  • Control of Trypanosoma brucei infection depends on non-MHC gene ability to produce IL-4. The 6th Scientific Conference, The Sudanese Association of Pathologists, Khartoum, Sudan. Sharga Hall, Khartoum, Sudan 5 January 1997.
  • Tyrosine kinases are required for interferon- stimulated proliferation of Trypanosoma brucei brucei. The 3rd Conference of the Federation of African Societies for Immunology, Cape Town, South Africa. 11 March 1997.
  • Interaction between T. b brucei and immunoregulating molecules The 30th Conference of the Arab Doctors, Sana’a Yemen. 15-17 July 1997
  • Recovery from Guillain Barrié syndrome is associated with increased levels of neutralizing autoantibodies to IFN-g. The 5th International Congress of human antibodies and hybridomas, 15-17 April 1998, Washington DC, USA. 15-17 April 1998
  • A nervous system induced factor inducing cytokines in immune cells. The International Summer School, Gothenburg, Sweden. 23-27 August 1998
  • A nervous system induced factor inducing cytokines in immune cells. The 5th International Congress of Neuroimmunology, Montreal, Canada. 25-2 July 1998
  • A major cession talk, the role of autoantibodies to cytokines, the 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, 9-12 September 1998, Stockholm, Sweden .The 14th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Stockholm, Sweden. 9-12 September 1998
  • Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The 31

Pan Arab Congress, Khartoum, Sudan, 7-8 December 1998

  • Bidirectional cell signalling system between African trypanosomes and CD8-neurons: implications for neuropsychiatric manifestations, prevention, diagnosis and treatment. The ITM colloquium Congress, Antwerp, Belgium 14-17 December 1998
  • Immunopathogenesis of experimental bacterial meningitis: Effects of immune modulation. The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000.
  • A nervous system induced factor inducing cytokines in immune cells. The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000
  • Tyrosine protein kinases are potentially involved during Trypanosoma brucei brucei derived lymphocyte triggering factor (TLTF) activation of dorsal root ganglia neurons. The 9th International Conference of Infectious Diseases, 9 -13 April 2000, Buenos Aires, Argentina
  • Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. The 4th annual Woods Hole Immunoparasitology Meeting, April 16 – 19, 2000 – MBL Woods Hole, MA, USA.
  • Rantes promotes growth of human embryonic astrocytes. Immunology 2000. The American Association of Immunologist and Clinical Immunology Society joint annual meeting. 12 – 16 May, 2000. Seattle, WA, USA.
  • Interferon-g induces production of the trypanosome lymphocyte triggering factor via tyrosine protein kinases. The 10th European Congress of Clinical Microbiology and Infectious Diseases. May 28 – 31, 2000 – Stockholm, Sweden.
  • The mechanism of cytokine action. Does dose matter? August – 31, 2000. The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis- Stockholm, Sweden.
  • Rantes promotes growth of human embryonic astrocytes. April 21- 26, 2001. The 11th International Conference on phosphorylated protein. Melbourne, Australia.
  • Chemokine and chemokine receptors, The 11th International Congress of Immunology. 18-26 August 2001. Stockholm, Sweden.
  • Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for IFN-b in the treatment of multiple sclerosis. 20-22/4/2002 Second Al Ain International Immunology Meeting.
  • Induction of a and b chemokines by intestinal epithelial cells stimulated with Campylobacter jejuni. International Conference of Infectious Diseases – Cancun, Mexico – 3-7 March 2004.
  • Recent advances in Multiple Sclerosis – The 3rd Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine, Genetics and Inherited Diseases 8 February 2005
  • Campylobacter jejuni induces diverse kinetics and profiles of cytokine and chemokine genes by INT-407 cells – International Symposium on Antimicrobial Agents and Resistance – Seoul – South Korea, 27 April 2005
  • Acute ischemic brain stroke is associated with immune-mediated Chlamydia pneumoniae infection- Research strategies and clinical challenges in neuroscience – Intercontinental Hotel in Al-Ain. 29 November 2005.
  • Acute ischemic stroke is associated with immune-mediated Chlamydia pneumoniae infection. 12th International Conference Infectious Diseases – Lisbon, Portugal. 17 June 2006.
  • TNF-α and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents.The 6th International Symposium on Antimicrobial Agents and Resistance. Singapore 8 March 2007.
  • Moleculae Medicine frpm Genes to Community – The 5th Gulf Scientific Conference for Medical Students, Manama, Kingdom of Bahrain. November 22 – 2007
  • Announcing the discovery of ISRAA (Immune System Released Activating Agent). 12 March 2008.
  • A novel nervous system mediator. BDF Hospital – Bahrain. 29 April 2008.
  • A role for Chlamydia pneumoniae in inducing IL-10, IL-13, IL-18 and the chemokines CCL3-alpha, CCL3-beta and CCL5 in atherosclerotic patients. 13th ICID – Kuala Lumpur, Malaysia- June 22, 2008.
  • Experimental study design and grant writing. Kuwait University, Kuwait March 09, 2009.
  • New Strategies For Immunogenetic Interventions During Neurodegenerative Diseases: Is stem cell research a solution?. Kwuait University. Kuwait March 10, 2009.
  • A novel Immune system mediator (ISRAA) Kuwait University, Kuwait, March 11, 2009.
  • Immune system released activating agent. Ulm, Germany 12 May 2009.
  • A novel nervous-to-immune signalling mechanism mediating innate responses to infections, Miami, USA. 14th International Congress of Infectious Diseases. 11 March 2010.
  • Genomics influence in the post injury inflammatory response, Trauma & Accident & Emergency Conference, Abu Dhabi, UAE, 12 October 2010
  • A novel indicative biomarker and a therapeutic agent for immunodeficiency. 6th Annual European Biomarkers Summit, Molecular Diagnostics Europe and Single Cell Analysis Congress, London, UK. 18 – 19 May 2011.
  • ISRAA: Recent Advances with Great Hope for Mankind. 8th International Scientific Conference H.H. Princess Al Jawhara Centre for Molecular Medicine & Inherited Disorders. 28 – 29 November 2011.
  • ISRAA: Recent Advances with Great Hope for Mankind. 13th GCC Industrialists Conference, Riyadh, KSA 16 – 19 January 2012.

Other scientific merits:

Active participation in international scientific congresses:
15-16 June, 1992 First “Acrival meeting” on chemotherapy
of trypanosomiasis, Marseilles, France
3-4 June 1993 Commission of the European Community, COST Co-operation, Second Acrival COST meeting on Treatment of African Trypanosomiasis, Budapest Hungary
15-16 September 1993 27th Trypanosomiasis Seminar – London School of Hygiene and Tropical Medicine
22 October 1994 4th International Congress of neuroimmunology, RAI, Amsterdam, Holland
25-28 May 1995 XXVIth Annual meeting, Scandinavian Society for Immunology, Gothenburg, Sweden.
23-29 July 1995 9th International Congress of Immunology San Francisco, USA
2-6 September 1995 BSP meeting on trypanosomiasis and leishmaniasis Glasgow, UK
19 January 1996 Trypanosome Workshop, BMC, Uppsala, Sweden
24-27 May 1996 XXVIIth Annual meeting, Scandinavian Society for Immunology, Turku, Finland.
28-30 November 1996 Swedish Medical Association Annual meeting, Sweden
4-6 January 1997 The 6th Scientific Conference, The Sudanese
Association of Pathologists, Khartoum, Sudan
9-13 March 1997 The 3rd Conference of the Federation of African Societies for Immunology, Cape Town, South Africa
15-17 July 1997 The 30th Conference of the Arab Doctors, Sana’a Yemen.
14-16 September 1997 The 5th CFN Symposium on effects of toxicants on gene expression and intracellular signalling – Stockholm.
15-17 April 1998 The 5th International Congress of human antibodies and
hybridomas, 15-17 April 1998, Washington DC, USA.
25-2 July 1998 The International Summer School, Gothenburg, Sweden.
23-27 August 1998 The 5th International Congress of Neuroimmunology, Montreal, Canada
9-12 September 1998 The 14th Congress of the European Committee for treatment and research in multiple Sclerosis, Stockholm
7-11 November 1998 The 31 Pan Arab Congress, Khartoum, Sudan
14-17 December 1998 The ITM colloquium Congress, Antwerp, Belgium
27/6-2 July 1999 The 10th International Congress on Mucosal Immunity. Amsterdam. Holland.
28/8 – 2 September 1999 1999 meeting on HIV/AIDS and Cancer Biology – Baltimore, Maryland – USA
17/1 – 19 January 2000 The 2000 International Congress on Pediatrics. Jeddah, Saudi Arabia. 17-19 January 2000
9 -13 April 2000 The 9th International Conference of Infectious Diseases, , Buenos Aires, Argentina
April 16 – 19, 2000 The 4th annual Woods Hole Immunoparasitology Meeting, – MBL Woods Hole, MA, USA
12 – 16 May 2000 Immunology 2000. The American Association of Immunologist and Clinical Immunology Society joint annual meeting.. Seattle, WA, USA
May 28 – 31, 2000 The 10th European Congress of Clinical Microbiology and Infectious Diseases – Stockholm, Sweden.
August – 31, 2000 The Biogen Symposium, Novel approaches to treatment of early diagnosed multiple sclerosis, Sweden.
April 21- 26, 2001 The 11th International Conference on phosphorylated protein – Melbourne, Australia
August 26/8/2001 Chemokine and chemokine receptors- 11th International Congress of Immunology – Stockholm – Sweden
April 20-22/2002 Cytokines as novel therapeutic agents for neuroinflammatory disorders: a role for IFN-b in the treatment of multiple sclerosis Second Al Ain International Immunology Meeting.
June 16-21, 2002 11th International Congress of Mucosal Immunology, Orlando
October 16-17, 2002 3rd GCC Neurology Conference, Bahrain
February 20-23, 2003 The International Symposium of the Immune System in Health and Disease. Osaka, Japan
October 06-08, 2003 Saudi German Academy second international meeting, Jeddah, Saudi Arabia
December 09-12, 2004 International Symposium on Genetics, Dubai – UAE
March 03-07, 2004 International Congress f Infectious Diseases, Cancun, Mexico
February 08 -09, 2005 The 3rd Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine.
April 27 -29, 2005 The 5th International Symposium on Antimicrobial Agents and Resistance – Seoul – South Korea
November 27-29 2005 Research strategies and clinical challenges in neuroscience – Intercontinental Hotel in Al-Ain
March 26-27 2006 The 4th Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine
April 05-07 2006 First Pan Arab Conference on Genetics, Center for Arab Genomic Studies, Albustan Rotana, Dubai
June 15-18 2006 12th International Conference Infectious Diseases – Lisbon, Portugal
November 6 2006 The 5th Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine, Genetics and Inherited Diseases – Bahrain
March 07-09 2007 The 6th International Symposium on Antimicrobial Agents and Resistance (ISAAR). Singapore.
November 11-12 2007 The 6th Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine, Genetics and Inherited Diseases – Bahrain
November -20-22 2007 The 2nd Pan Arab Conference in Human Genetics, Dubai, United Arab Emirates.
November -20-22 2007 The 5th Gulf Scientific Conference for Medical Students, Manama, Kingdom of Bahrain.
June 19-22, 2008 13th International Congress of Infectious Diseases (ICID) – Kuala Lumpur, Malaysia-
February 10-11, 2009 The 7th Scientific Conference, HH Princess Al-Jawhara centre for Molecular Medicine
May 09-12, 2009 The 23rd European Immunogenetics and Histochompatibility Congress. Ulm, Germany
October 11-13, 2009 Trauma & Accident & Emergency Conference, Abu Dhabi, UAE, 12 October 2010
January 24, 2010 Medical Genomics Research Conference, Dubai, UAE
March 09-12, 2010 14th International Congress on Infectious Diseases, Miami, USA
March 14-17, 2011 Human Genome Meeting (HGM) and 4th Pan Arab Human Genetics Conference, Dubai, UAE 14-17 March 2011.
May 18-19, 2011 6th annual European Biomarkers Summit, Molecular Diagnostics Europe and Single Cell Analysis Congress, London, UK
Nov 28-29, 2011 ISRAA: Recent Advances with Great Hope for Mankind. 8th International Scientific Conference. H.H. Princess Al Jawhara Centre for Molecular Medicine & Inherited Disorders.
Jan 16-19, 2012 ISRAA: Recent Advances with Great Hope for Mankind. . 13th GCC Industrialists Conference, Riyadh, KSA 16 – 19 January 2012.

Fellowships and scholarships

1988-1991 Departmental Fellowship, Departments of Neurology and neurobiology, Karolinska Institute, Huddinge University Hospital
1991-1992 Training allowance from Karolinska Institute
1992-1994 WHO, TDR fellowship
1995-1999 Medical Research Council (MRC) Research Position
1999- 2001 Karolinska Institute Research Position

Scientific collaboration and external research grants

SCIENTIFIC COLLABORATION:

  • Professor Hans Wigzell, MTC, Karolinska Institute, Stockholm, Sweden.
  • Professor Jan Andersson, Division of Infectious Diseases, Huddinge Hospital, Sweden.
  • Professor John Donelson, Howard Hughes Medical Center, University of Iowa USA.
  • Professor CC Wang, Department of Chemistry, University of California, USA.
  • Dr. William Kuzel, Institute for Cellular and Molecular Biology, University of Texas
  • Professor Phillipe Büscher, Institute of Tropical Medicine, Antwerp, Belgium.
  • Professor Peter van der Meide, TNO Center, Rijswijk, The Netherlands.
  • Dr. Eilhard Mix, University of Rostock, Department of Neurology, Germany.
  • Dr. Abdel Rahman Tambal, Director General National Health Laboratories, Khartoum
WORK IN LABORATORIES OUTSIDE SWEDEN:

  • Institute of Tropical Medicine, Antwerp, Belgium, May – June 1994.
  • Department of Biochemistry, Howard Hughes Medical Center, University of Iowa USA. June – July 1995.
  • Neuroimmunology lab, University of Rostock, Germany, November 1993, December 1994.
  • Visited the following labs for sharing experience:
  • Hopital Robert Debre – Paris – France (2003)
  • Hopital Saint-Louis – Paris – France (2003)
  • Center Hopitalier Universitaire de Rouen – France (2003)
  • King Faisal Specialist Hospital and Research Center – Riyadh, Saudi Arabia (2003)
  • Centre for Molecular Psychiatry – University of London. (2005).

Statement of the current granted research funds

Strategic Research, Junior Promising Researcher 550.000 SEK
MFR 486.000 + 330.000 SEK
WHO, Director Initiative Fund 120.000 SEK
Kapten Artur 100.000 SEK
KI-FOND 46.000 SEK
SLS 70.000 SEK
Magn Begvalls Stiftelse 40.000 SEK
A Eriksson 20.000 SEK
FoUU 600.000 SEK
Harald och Greta Jeanssons Stiftelse 130.000 SEK
AGU, Campylobacter Project 20.000 BD (500.000 SEK)
AGU, Trypanosoma Project 15.000 BD (37500.000 SEK)
AGU, Stroke Project 5.000 BD (12500.000 SEK)
AGU, ISRAA Signalling and Innate Immunity

Dr. Ali Al-Khalifa Research Fund

20.000 BD (500.000 SEK)

08.000 BD (200.000 SEK)

Supervision of doctoral candidates/postgraduate teaching

Graduated scientists under my supervision:

Ph.D. degree

  • Asim Diab, June 1998
  • Alyaa Mousa, December 1998
  • Rihab Elkarim, 18 October 1999
  • Ragaa Eltayeb 12 October 2000
  • Ahmed Sharafeldin December 2001
  • Maha Hamadien 30 August 2002
  • Najat Alhashimi: 26 August 2004

Licentiate (M Phil) degree

  • Najat Alhashimi: 23 August 1999
  • Maha Hamadien: 25 August 1999
  • Liu Yajuan: 29 October 1999
  • Ahmed Sharafeldin 8 November 1999
  • Hana Abdalla, 10 March 2000.

Master degree

  • Anneli Tjernlund, June 1998
  • Pontus Thulin, August 2000
  • Fajer Al-Saloom, October 2002
  • Amani Alzaki Feb 2004
  • Habib Yousif MArch 2004
  • Ahlam Alamri April 2004
  • Ali Albahrani April 2005
  • Abdulhadi Ali Al-bannawi July 2005
  • Khulood Suliman Al-Wesebai November 2005
  • Asma Abdulla Abdulghafour September 2007
  • Jenan Ahmad Al-Matouq. November 2008
  • Zainab Ashkanan. December 2008
  • Razan Ahmed Fakieh. March 2009
  • Huda Mossa Omran, May 2011
Registered Ph.D. students

New 5 PhD students are registered under the Molecular Medicine PhD Program

Master student, agu:

New 3 Master students are registered under the Biotechnology Program

Visiting professor:

Faculty of medicine, University of Kuwait: 6 – 12 March 2009